Organ barrier

Therapeutic targeting of microbiota or organ barriers

Data analysis

Technological analysis platforms


Mibiogate project partners are also involved in preclinical or clinical projects and in the elaboration of new projects thanks to the development of the Mibiogate network. Mibiogate encourages communication and exchange between the players in the Greater western region, through the organization of scientific seminars as well as the development and highlighting of expertise through research projects and communication/promotion initiatives. The following are examples of structuring projects resulting from or related to Mibiogate on the themes: microbiota/biological barriers/chronic diseases.

POCA Projects

Category :


Abstract  :

Inflammation of the intestinal reservoir (pouchitis) in patients with ulcerative colitis (UC) involves a deregulated inflammatory response to intestinal bacteria. Modification of this microbiota by a faecal microbiota transplantation (FMT) could modulate this response and prevent a possible relapse.

Main objective :

Compare chronic pouchitis time to relapse after faecal transplantation versus fictive transplantation in patients with ileal pouch-anal anastomosis in the context of ulcerative colitis.

Secondary objectives :

1. Efficacy of FMT on relapse rate at 24 weeks and 52 weeks.

2. Initiation of alternative treatment within 52 weeks after FMT.

3. FMT safety in the event of pouchitis.

4. Faecal microbiota modification in patients with recurrent chronic pouchitis in remission after antibiotic therapy and at 8 weeks of FMT from a healthy donor

5. Evolution of disability.

Two biocollections will be established and centralised at Nantes University Hospital. One will collect donor faeces samples and the other patient biopsies and faeces samples.

Results or projected end date :

first patient enrolment in May 2018

Partners involved :

CHU de Nantes

Project lead contact :

Dr Caroline Trang-Poisson

Funding source :



Category :


Abstract :

Study aimed at evaluating the efficacy of antenatal maternal supplementation with GOS/Inulin prebiotics on the occurrence of atopic dermatitis in one-year old infants with atopic risk.

Results or projected end date :

Study in progress/end date: January 2021

Partners involved :

INRA BIA (allergy)
University Hospital Nantes (patient cohort)

Project lead contact :

Marie Bodinier (INRA)

Sébastien Barbarot (CHU Nantes)

Source de financement :

PHRC inter-regional

Promotion/Publication :

Publication :

This clinical study is associated with an ancillary study, CIMMAP, funded by the ANR (Collaborative Research Project: Translational Health Research). CIMMAP, coordinated by Marie Bodinier (UR1268 BIA, Allergy team), explores the perinatal period in children at risk of allergy by focusing on the development of the immune system (IS) and microbiota; the effects of breast milk on these parameters; the modulation of the infantile IS by maternal microbiota and its derivatives; the effects of prebiotics on the IS/microbiota/milk. A preclinical model shall specify the mechanisms at an organic level. CIMMAP will assist in refining the pathophysiology of allergies and in identifying the risk and tolerance biomarkers.